Which syndrome is characterized by bilateral panuveitis and nasal planum depigmentation?

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The syndrome characterized by bilateral panuveitis and nasal planum depigmentation is the Uveodermatologic syndrome. This condition is primarily seen in certain breeds, such as akitas and huskies, and it involves a combination of uveitis—an inflammation of the uveal tract in the eye—and dermatological changes, including depigmentation of the skin, particularly on the nasal planum.

In Uveodermatologic syndrome, the immune system mistakenly attacks melanocytes, leading to the characteristic skin depigmentation. The bilateral panuveitis reflects the systemic nature of the immune response, where inflammation affects both eyes. The presence of these two clinical signs—ocular inflammation and skin depigmentation—is a defining feature of the syndrome, distinguishing it from other forms of uveitis that do not result in similar cutaneous manifestations.

Other conditions listed may involve uveitis but lack the additional skin changes that define this syndrome. Thus, Uveodermatologic syndrome is recognized as the primary condition associated with both features presented in the question.

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