Which of the following is a common clinical sign of chronic uveitis?

Iris hyperpigmentation is a common clinical sign of chronic uveitis. This condition refers to the inflammation of the uveal tract, which includes the iris, ciliary body, and choroid. In chronic cases, ongoing inflammation can lead to changes in the pigmentation of the iris as a response to the persistent irritation and altered cellular dynamics within the eye. Hyperpigmentation often manifests as darker areas on the iris and is indicative of a long-standing inflammatory process.

In contrast, ciliary flush typically presents in acute uveitis, where there is a ring of redness around the cornea due to increased blood flow. Aqueous flare, which indicates the presence of inflammation in the aqueous humor, is often more acute than chronic. Hypopyon, the accumulation of pus in the anterior chamber, indicates a severe inflammatory response and is considered more an acute finding rather than one typically seen in chronic uveitis. Thus, iris hyperpigmentation stands out as a hallmark characteristic of chronic uveitis as it reflects the long-term alterations in the iris due to sustained inflammation.