Which medication is recommended for prophylaxis in the unaffected eye for glaucoma?

Timolol is a non-selective beta-adrenergic antagonist that is commonly used for the management of intraocular pressure in glaucoma. It is particularly effective in lowering intraocular pressure and is often recommended for prophylactic use in the unaffected eye of patients diagnosed with glaucoma. The rationale behind this practice is that individuals with glaucoma are at risk for developing the condition in both eyes, and using Timolol can help prevent or delay the onset of glaucoma in the unaffected eye by reducing aqueous humor production and lowering intraocular pressure.

Other medications listed, such as prednisolone, are primarily anti-inflammatory and do not address intraocular pressure; thus they are not suitable for prophylaxis against glaucoma. Neopolydex, an antibiotic-steroid combination, is also focused on treating infections and inflammation rather than managing intraocular pressure. Mannitol is an osmotic diuretic used in acute situations to rapidly reduce intraocular pressure but is not used for long-term prophylaxis in unaffected eyes. Therefore, Timolol is the most appropriate choice for this specific indication.