Which chemical mediators are associated with uveitis?

Uveitis, which is the inflammation of the uveal tract in the eye, involves various chemical mediators that play critical roles in the inflammatory processes. Substance P and prostaglandins are particularly significant in this context.

Substance P is a neuropeptide involved in the transmission of pain and is associated with inflammatory responses. Its release can amplify the inflammatory process, contributing to the symptoms of uveitis, such as pain and discomfort.

Prostaglandins, which are lipid compounds derived from arachidonic acid, are also crucial in mediating inflammation. They promote vasodilation, increase vascular permeability, and attract immune cells to the site of inflammation, which are all vital processes in the pathogenesis of uveitis.

Together, these mediators facilitate the development of uveitis by promoting inflammation and pain, leading to clinical signs associated with the condition. Their roles in inducing and sustaining inflammatory responses are well-documented, making this option the most accurate in the context of uveitis.