Which cell types are commonly involved in the immune-mediated condition of Proliferative/Eosinophilic Keratitis?

Eosinophilic keratitis is a specific immune-mediated ocular condition, most commonly seen in certain breeds of cats and dogs. The characteristic feature of this condition is the presence of eosinophils, which are a type of white blood cell primarily involved in allergic reactions and parasitic infections. In cases of eosinophilic keratitis, eosinophils infiltrate the corneal tissue and contribute to the inflammatory process.

Plasma cells, which produce antibodies, also play a role in this condition as part of the adaptive immune response. The presence of these cells indicates an ongoing immune reaction, where the body is attempting to fight off a perceived threat, leading to keratitis. The combination of eosinophils and plasma cells signifies a strong allergic or hypersensitivity reaction characteristic of proliferative/eosinophilic keratitis.

Understanding the roles of these cell types in the context of this condition is vital for diagnosing and developing treatment strategies targeting the underlying immune-mediated response.