What is a possible consequence of corneal endothelial disruption?

Corneal endothelial disruption leads to a loss of the cornea's ability to maintain proper hydration and transparency. The endothelium is responsible for actively pumping excess fluid out of the corneal stroma to keep the cornea clear and properly hydrated. When this layer is damaged or dysfunctional, fluid accumulates within the corneal stroma, resulting in corneal edema. This condition is characterized by a cloudy or swollen appearance of the cornea and can impair vision.

Cataract formation, corneal scarring, and corneal perforation can be associated with other ocular conditions or complications, but they do not directly result from the disruption of the corneal endothelium in the same way that corneal edema does. Therefore, the direct consequence of endothelial damage is the inability to regulate corneal hydration, leading to edema.