What condition may be associated with endothelial disruption in the cornea?

Uveitis, an inflammation of the uveal tract in the eye, can lead to a breakdown of the blood-ocular barrier and affect the corneal endothelium. When uveitis occurs, there is an increased permeability of the endothelial cells, allowing inflammatory cells and proteins to infiltrate. This can result in changes to the corneal endothelium, potentially leading to corneal edema and opacity due to fluid accumulation in the corneal stroma.

The other conditions listed are not typically associated with endothelial disruption. Corneal fibrosis involves the formation of scar tissue within the cornea but does not directly impact the endothelial layer. A corneal sequestrum is characterized by an area of necrotic corneal tissue, primarily in cats, but it does not stem from disruptions to the endothelium. Keratitis, which is the inflammation of the cornea, may involve the epithelial and stromal layers, but it usually does not directly affect the endothelium in the same way that uveitis does. Therefore, uveitis is the condition most closely linked to endothelial disruption in the cornea.