Enucleation is considered in cases of uveitis when:

Enucleation is indicated in cases of uveitis particularly when there is a blind and painful eye. Uveitis can lead to chronic pain, inflammation, and damage to the eye, resulting in loss of vision. When an eye has become non-functional, meaning that it cannot perceive visual stimuli, and is associated with significant discomfort or pain for the patient, removing the eye (enucleation) is often the best option to alleviate suffering.

This intervention is generally considered a humane solution when conservative treatments fail to manage pain and inflammation adequately. The focus is on improving the patient's quality of life, so enucleation becomes a viable option to remove both the source of pain and avoid further complications associated with a painful, blind eye.